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Adv Drug Deliv Rev. 2008 Jan 14;60(2):184-98. Epub 2007 Nov 28.

Biomimetic materials for tissue engineering.

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1
Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109-1078, USA. mapx@umich.edu

Abstract

Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or wound healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/wound healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.

PMID:
18045729
PMCID:
PMC2271038
DOI:
10.1016/j.addr.2007.08.041
[Indexed for MEDLINE]
Free PMC Article
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