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Mov Disord. 2008 Jan 30;23(2):302-5.

Telomere length and risk of Parkinson's disease.

Author information

1
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. hwangi@hsph.harvard.edu

Abstract

We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.

PMID:
18044760
PMCID:
PMC2387100
DOI:
10.1002/mds.21867
[Indexed for MEDLINE]
Free PMC Article
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