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Clin Interv Aging. 2007;2(3):327-35.

Vascular dementia: pharmacological treatment approaches and perspectives.

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1
Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, California, USA. abaskys@uci.edu

Abstract

Vascular dementia is a common condition for which there are no effective approved pharmacological treatments available. Absence of effective treatments creates a difficult situation for those suffering from the disease, their caregivers, and healthcare providers. This review will address our current understanding of the mechanisms of nerve cell damage due to ischemia and summarize available clinical trial data on several commonly used compounds including memantine, donepezil, galantamine, rivastigmine, nimodipine, hydergine, nicergoline, CDP-choline, folic acid, as well as such nonpharmacological approaches as validation therapy.

PMID:
18044183
PMCID:
PMC2685259
[Indexed for MEDLINE]
Free PMC Article
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