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Nat Rev Mol Cell Biol. 2008 Jan;9(1):60-71.

Heterotrimeric G protein activation by G-protein-coupled receptors.

Author information

1
Department of Pharmacology, Vanderbilt University School of Medicine, 442 Robinson Research Building, 2222 Pierce Avenue, Nashville, TN 37232-6600, USA.

Abstract

Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit. The complex series of interactions and conformational changes that connect agonist binding to G protein activation raise various interesting questions about the structure, biomechanics, kinetics and specificity of signal transduction across the plasma membrane.

PMID:
18043707
DOI:
10.1038/nrm2299
[Indexed for MEDLINE]

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