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Curr Opin Oncol. 2008 Jan;20(1):112-21.

State-of-the-art in the treatment of chronic myeloid leukaemia.

Author information

1
Department of Haematology, The Hammersmith Hospital, London, UK. d.milojkovic@imperial.ac.uk

Abstract

PURPOSE OF REVIEW:

To revise the current goals of therapy of chronic myeloid leukaemia and to incorporate the influence of the underlying chronic myeloid leukaemia biology on directing therapeutic management.

RECENT FINDINGS:

The management of chronic myeloid leukaemia has been revolutionized by targeted molecular therapy that inhibits the ABL kinase activity of the BCR-ABL gene. The achievement of a major molecular response with the first tyrosine kinase inhibitor to be introduced into clinical practice, imatinib, is a focus of therapeutic regimens. Second-generation tyrosine kinase inhibitors are available that have more potent effects than imatinib, and have activity against imatinib-resistant subclones. Strategies to overcome the restoration of BCR-ABL signalling and subsequent resistance to therapy include imatinib dose escalation, a more potent tyrosine kinase inhibitor, as well as non-BCR-ABL-dependent approaches and agents in clinical development.

SUMMARY:

Therapeutic advances in chronic myeloid leukaemia continue to circumvent the challenges of drug resistance and the minimal residual leukaemic burden providing effective strategies for future therapy.

PMID:
18043265
DOI:
10.1097/CCO.0b013e3282f1fe8a
[Indexed for MEDLINE]

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