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Mol Cell. 2007 Nov 30;28(4):522-9.

Send in the clamps: control of DNA translesion synthesis in eukaryotes.

Author information

1
Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

Abstract

The replication of damaged DNA templates by translesion synthesis (TLS) is associated with mutagenesis and carcinogenesis. This perspective discusses the different levels at which TLS may be controlled and proposes a model for TLS of severely helix-distorting DNA lesions that includes a decisive role for the Rad9-Hus1-Rad1 DNA-damage-signaling clamp. The dual involvement of this clamp in both DNA-damage signaling and TLS may have profound implications in determining cellular responses to DNA damage.

PMID:
18042449
DOI:
10.1016/j.molcel.2007.11.005
[Indexed for MEDLINE]
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