To kill or to arrest: that is the new question for Apaf-1

Mol Cell. 2007 Nov 30;28(4):520-1. doi: 10.1016/j.molcel.2007.11.007.

Abstract

In this issue of Molecular Cell, Zermati et al. (2007) report that Apaf-1 is essential for the DNA damage-induced intra-S phase checkpoint response. This new role for Apaf-1 is unrelated to its proapoptotic function but is evolutionarily conserved in Ced-4.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis*
  • Apoptotic Protease-Activating Factor 1 / deficiency
  • Apoptotic Protease-Activating Factor 1 / metabolism*
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins / metabolism
  • Calcium-Binding Proteins / metabolism
  • Carcinoma, Non-Small-Cell Lung / enzymology
  • Cell Cycle
  • DNA Damage*
  • Humans
  • Lung Neoplasms / enzymology
  • Mice

Substances

  • Apoptotic Protease-Activating Factor 1
  • Caenorhabditis elegans Proteins
  • Calcium-Binding Proteins
  • Ced-4 protein, C elegans