Abstract
In this issue of Molecular Cell, Zermati et al. (2007) report that Apaf-1 is essential for the DNA damage-induced intra-S phase checkpoint response. This new role for Apaf-1 is unrelated to its proapoptotic function but is evolutionarily conserved in Ced-4.
MeSH terms
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Animals
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Apoptosis*
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Apoptotic Protease-Activating Factor 1 / deficiency
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Apoptotic Protease-Activating Factor 1 / metabolism*
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Caenorhabditis elegans / cytology
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins / metabolism
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Calcium-Binding Proteins / metabolism
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Carcinoma, Non-Small-Cell Lung / enzymology
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Cell Cycle
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DNA Damage*
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Humans
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Lung Neoplasms / enzymology
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Mice
Substances
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Apoptotic Protease-Activating Factor 1
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Caenorhabditis elegans Proteins
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Calcium-Binding Proteins
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Ced-4 protein, C elegans