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Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. Epub 2007 Nov 17.

Design and synthesis of a fluorescent muscarinic antagonist.

Author information

1
Discovery Chemistry, Sandwich Laboratories, Pfizer Research and Development, Ramsgate Rd, Kent CT2 8DR, UK. lyn.jones@pfizer.com

Abstract

The design and concise synthesis of a fluorescent tolterodine-BODIPY (boron dipyrromethene) conjugate is described which possesses potent antimuscarinic activity. This derivative illustrates proof-of-concept for the preparation of other useful fluorophoric antimuscarinic agents which have potential utility in receptor occupancy studies and high throughput screens.

PMID:
18042383
DOI:
10.1016/j.bmcl.2007.11.022
[Indexed for MEDLINE]

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