Abstract
A Pasteurella multocida human isolate was resistant to beta-lactams because of production of ROB-1 beta-lactamase. The beta-lactamase was encoded by a 4.3-kb plasmid closely related to that of a Pasteurella bovine strain, as shown by Sau3A restriction profile and hybridization with a plasmid probe containing the blaROB-1 gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology
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Cattle
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DNA, Bacterial / analysis
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Drug Resistance, Microbial / genetics
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Humans
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Nucleic Acid Hybridization
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Pasteurella / enzymology*
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Pasteurella / genetics
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Pasteurella Infections / microbiology
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Plasmids
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Transformation, Bacterial
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beta-Lactamases / biosynthesis*
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beta-Lactams
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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beta-Lactams
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beta-Lactamases