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J Bacteriol. 2008 Feb;190(3):1128-33. Epub 2007 Nov 26.

Role of stress response sigma factor SigG in Mycobacterium tuberculosis.

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1
Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, CRB2, Room 1.08, 1550 Orleans Street, Baltimore, MD 21231-1044, USA.

Abstract

The sigG gene of Mycobacterium tuberculosis was disrupted by homologous recombination, and the genes regulated by SigG were examined by real-time reverse-transcription PCR and microarray studies. The SigG consensus promoter recognition sequence was identified as GCGNGT-N15-18-CGANCA. A DeltasigG mutant was found to be more resistant to mitomycin C treatment than the wild-type strain, indicating that it may be involved in the SOS response in M. tuberculosis.

PMID:
18039768
PMCID:
PMC2223564
DOI:
10.1128/JB.00511-07
[Indexed for MEDLINE]
Free PMC Article
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