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Nat Clin Pract Rheumatol. 2007 Dec;3(12):716-24.

Adipokines as emerging mediators of immune response and inflammation.

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  • 1Molecular and Cellular Cardiology Research Laboratory, Santiago University Clinical Hospital, Santiago de Compostela, Spain.

Abstract

The scientific interest in the biology of white adipose tissue (WAT) has increased since the discovery of leptin in 1994. The description of the product of the gene obese (ob) demonstrated the role of adipose tissue in the physiopathology of obesity-related diseases, and helped to increase the identification of numerous other adipokines, many of a pro-inflammatory nature. It has become increasingly evident that WAT-derived adipokines can be considered as a hub between obesity-related exogenous factors, such as nutrition and lifestyle, and the molecular events that lead to metabolic syndrome, inflammatory and/or autoimmune conditions, and rheumatic diseases. In this Review, we will discuss the progress in adipokine research, focusing particular attention to the roles of leptin, adiponectin, resistin, visfatin, and other recently identified adipokines in inflammatory, autoimmune and rheumatic diseases.

PMID:
18037931
DOI:
10.1038/ncprheum0674
[PubMed - indexed for MEDLINE]
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