Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2007 Dec;8(12):995-1005.

Predicting protein function from sequence and structure.

Author information

  • 1Biomolecular Structure and Modelling Group, Department of Biochemistry and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK.


While the number of sequenced genomes continues to grow, experimentally verified functional annotation of whole genomes remains patchy. Structural genomics projects are yielding many protein structures that have unknown function. Nevertheless, subsequent experimental investigation is costly and time-consuming, which makes computational methods for predicting protein function very attractive. There is an increasing number of noteworthy methods for predicting protein function from sequence and structural data alone, many of which are readily available to cell biologists who are aware of the strengths and pitfalls of each available technique.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center