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Gynecol Oncol. 2008 Feb;108(2):415-20. Epub 2007 Nov 26.

Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma.

Author information

1
Fingerland Department of Pathology, Charles University, Medical School and Teaching Hospital, Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. tomsova@fnhk.cz

Abstract

OBJECTIVE:

Epithelial ovarian cancer (EOC) is the most common cause of death among gynecological malignancies in Europe and North America. Although the presence of tumor-infiltrating mononuclear cells has been documented in EOC, the association of tumor-infiltrating mononuclear cells with clinical outcome remains controversial. The aim of the present study was to investigate the prognostic significance of CD3+ tumor-infiltrating T lymphocytes (TIL) on overall survival of EOC patients.

METHODS:

We evaluated retrospectively by immunohistochemistry the distribution of CD3+ TIL in tumor specimens of 116 EOC patients. The expression of estrogen and progesterone receptors, Ki-67, DNA topoisomerase IIalpha, p21, p53, HER-2/neu, bax and bcl-2 was also evaluated by immunohistochemistry. The prognostic significance of CD3+ TIL and other immunohistochemical and clinical parameters was evaluated with log-rank test. Multivariate analysis was performed using the Cox regression.

RESULTS:

CD3+ TIL were observed in all tumor samples, both in cancer stroma and within cancer epithelium (intraepithelial TIL). The median counts of stromal TIL and intraepithelial TIL were 338 lymphocytes/mm2 (range 81-2094 lymphocytes/mm2) and 125 lymphocytes/mm2 (range 7-481 lymphocytes/mm2), respectively. In univariate analysis, age, stage, grade, presence of residual tumor, expression of progesterone receptors, Ki-67, DNA topoisomerase IIalpha and intraepithelial CD3+ TIL count were significant predictors of overall survival. On multivariate analysis, only the presence of residual tumor, stage, expression of progesterone receptors and intraepithelial CD3+ TIL count were found to be significant independent predictors of overall survival.

CONCLUSION:

Present data indicate that the intraepithelial CD3+ TIL count is a significant prognostic factor in EOC.

PMID:
18037158
DOI:
10.1016/j.ygyno.2007.10.016
[Indexed for MEDLINE]
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