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J Pediatr. 2007 Dec;151(6):571-4. Epub 2007 Oct 24.

Effect of 1-desamino-8-D-arginine vasopressin on prepulse inhibition of startle supports a central etiology of primary monosymptomatic enuresis.

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1
University Clinics of Schleswig-Holstein, Campus Kiel, Department of Pediatrics, Kiel, Germany.

Abstract

OBJECTIVE:

To test the hypothesis that 1-desamino-8-D-arginine vasopressin (dDAVP) has an effect on prepulse inhibition (PPI) of startle in patients with primary monosymptomatic enuresis (PME), thus indicating a central effect.

STUDY DESIGN:

Patients with PME (n = 21, age 6 to 12 years) were enrolled in a prospective, randomized, double-blinded, cross-over study. Startle reflexes and PPI were measured under dDAVP treatment versus placebo.

RESULTS:

The data show that dDAVP has a significant effect on PPI, raising it from 38.88% under placebo to the age-related normal level of 62.6% with dDAVP treatment (P = .0127).

CONCLUSIONS:

Our findings revive the concept of a central pathophysiology of PME and offer a different explanation for the effects of dDAVP, which not only acts on the kidney, but also is (as is AVP) a central neurotransmitter with a signal cascade on relevant reflex mechanisms.

PMID:
18035131
DOI:
10.1016/j.jpeds.2007.05.024
[Indexed for MEDLINE]
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