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J Int Med Res. 2007 Nov-Dec;35(6):796-802.

Effect of ongoing inflammation in rheumatoid arthritis on P-wave dispersion.

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  • 1Department of Cardiology, Firat University, School of Medicine, Elazig, Turkey. mfyavuzkir@firat.edu.tr

Abstract

It has been emphasized recently that there is a strong association between atrial fibrillation and inflammation. Rheumatoid arthritis (RA), characterized by ongoing inflammatory activity, can increase the risk of atrial arrhythmia. P-wave dispersion has been encountered as a risk factor for atrial fibrillation and the effect of inflammation on P-wave dispersion has not been studied thoroughly. The aim of this study was to examine the effect of ongoing inflammatory activity in RA on P-wave dispersion. The study comprised 82 patients diagnosed with RA and 41 healthy volunteers as controls. Systolic functions of all participants were evaluated by echocardiography. Maximum P-wave duration and dispersion were calculated and found to be significantly increased in the RA group compared with the healthy controls. These parameters were also significantly correlated with C-reactive protein levels. The findings of this study suggest that RA may be associated with increases in P-wave dispersion and maximum P-wave duration, and that this association may result from ongoing inflammation.

PMID:
18034993
DOI:
10.1177/147323000703500608
[PubMed - indexed for MEDLINE]
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