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Bioorg Med Chem Lett. 2008 Jan 1;18(1):137-40. Epub 2007 Nov 4.

Sulfonate chalcone as new class voltage-dependent K+ channel blocker.

Author information

1
Department of Physiology, School of Medicine and Institute of Health Science, Gyeongsang National University, Jinju 660-701, Republic of Korea.

Abstract

Chalcone derivatives 1-17 were synthesized and their voltage-dependent K+ channel inhibitory activities were investigated. The effective K+ channel blockers were shown to be sulfonate chalcones 9-17, in which the sulfonyloxy group is placed on the A-ring. The 3'-(p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC50 = 0.51+/-0.05 microM) was the most potent K+ channel blocker.

PMID:
18032041
DOI:
10.1016/j.bmcl.2007.10.114
[Indexed for MEDLINE]

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