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Phys Med Biol. 2007 Dec 7;52(23):6923-30. Epub 2007 Nov 8.

High-resolution brain tumor visualization using three-dimensional x-ray phase contrast tomography.

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Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland. <>


We report on significant advances and new results concerning a recently developed method for grating-based hard x-ray phase tomography. We demonstrate how the soft tissue sensitivity of the technique is increased and show in vitro tomographic images of a tumor bearing rat brain sample, without use of contrast agents. In particular, we observe that the brain tumor and the white and gray brain matter structure in a rat's cerebellum are clearly resolved. The results are potentially interesting from a clinical point of view, since a similar approach using three transmission gratings can be implemented with more readily available x-ray sources, such as standard x-ray tubes. Moreover, the results open the way to in vivo experiments in the near future.

[Indexed for MEDLINE]

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