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Phys Med Biol. 2007 Dec 7;52(23):N531-7. Epub 2007 Nov 6.

Three-dimensional optical micro-angiography maps directional blood perfusion deep within microcirculation tissue beds in vivo.

Author information

1
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA. r.k.wang@bme.ogi.edu

Abstract

Optical micro-angiography (OMAG) is a recently developed method of imaging localized blood perfusion at capillary level resolution within microcirculatory beds. This paper reports that the OMAG is capable of directional blood perfusion mapping in vivo. This is achieved simply by translating the mirror located in the reference arm back and forth while 3D imaging is performed. The mirror which moves toward the incident beam gives the blood perfusion that flows away from the beam direction and vice versa. The approach is experimentally demonstrated by imaging of a flow phantom and then cerebro-vascular perfusion of a live mouse with cranium intact.

PMID:
18029974
DOI:
10.1088/0031-9155/52/23/N01
[Indexed for MEDLINE]

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