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Swiss Med Wkly. 2007 Nov 17;137(45-46):625-34.

CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.

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1
Division of Gastroenterology & Hepatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. christian.mottet@chuv.ch

Abstract

Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.

PMID:
18027108
DOI:
2007/45/smw-11916
[Indexed for MEDLINE]
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