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Br J Pharmacol. 2008 Mar;153 Suppl 1:S35-43. Epub 2007 Nov 19.

Intracellular machinery for the transport of AMPA receptors.

Author information

1
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA. estebanj@umich.edu

Abstract

AMPA-type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors reach their synaptic targets after a complicated journey involving multiple transport steps through different membrane compartments. This review summarizes our current knowledge of the trafficking pathways of AMPARs and their relation to synaptic function and plasticity.

PMID:
18026130
PMCID:
PMC2268045
DOI:
10.1038/sj.bjp.0707525
[Indexed for MEDLINE]
Free PMC Article
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