Frequencies of HLA-DR3, -DR4, -B8 and -Bw62 in diabetic children diagnosed between 1960 and 1990

A Mäenpää; S Koskimies; T Scheinin; A Schlenzka; H K Akerblom; J Mäenpää; A Reunanen; S Kontiainen

Frequencies of HLA-DR3, -DR4, -B8 and -Bw62 in diabetic children diagnosed between 1960 and 1990

Diabetes Res. 1991 Apr;16(4):159-63.

Authors

A Mäenpää¹, S Koskimies, T Scheinin, A Schlenzka, H K Akerblom, J Mäenpää, A Reunanen, S Kontiainen

Affiliation

¹ Department of Pathology, University of Helsinki, Finland.

PMID: 1802481

Abstract

An analysis of the HLA-types of 351 children in whom a diagnosis of insulin dependent diabetes mellitus (IDDM) had been made between 1960 and 1990 revealed that although the frequencies of HLA-DR3, -DR4, -DR3/4, -B8 and -Bw62 were increased there was, depending on the year of diagnosis, a marked fluctuation in the frequencies of these HLA-antigens and in the frequency with which -B8 was associated with -DR3 and -Bw62 with -DR4 suggesting heterogeneity/variation in agents initiating/triggering IDDM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chickenpox / epidemiology
Child
Diabetes Mellitus, Type 1 / epidemiology
Diabetes Mellitus, Type 1 / immunology*
Finland / epidemiology
HLA-B Antigens / analysis*
HLA-B15 Antigen
HLA-B8 Antigen / analysis*
HLA-DR3 Antigen / analysis*
HLA-DR4 Antigen / analysis*
Histocompatibility Testing
Humans
Incidence
Measles / epidemiology
Mumps / epidemiology
Probability
Retrospective Studies
Urban Population

Substances

HLA-B Antigens
HLA-B15 Antigen
HLA-B8 Antigen
HLA-Bw62
HLA-DR3 Antigen
HLA-DR4 Antigen