Format

Send to

Choose Destination
See comment in PubMed Commons below
J Vet Cardiol. 2007 Nov;9(2):63-8. Epub 2007 Nov 19.

Effect of spironolactone on diuresis and urine sodium and potassium excretion in healthy dogs.

Author information

1
UMR181 de Physiopathologie et Toxicologie Expérimentales INRA, ENVT, National Veterinary School, 23 chemin de Capelles, 31076 Toulouse cedex 03, France.

Abstract

OBJECTIVES:

To document the diuretic effect of different oral doses of spironolactone (SP) in healthy dogs.

BACKGROUND:

SP is currently mentioned as a diuretic agent in the dog. However, the recommended doses were empirically defined and their corresponding diuretic effect has never been documented in dogs.

ANIMALS, MATERIALS AND METHODS:

Eight adult Beagle dogs were used for two separate 2*2 cross-over designs. In the first cross-over, 4 dogs received SP orally for 8 days at 1 and 2mg/kg per day. In the second cross-over the 4 other dogs received SP similarly, but at 4 and 8 mg/kg per day. Dogs were weighed on the first and last day of each period. Plasma SP and canrenone (the main active metabolite of SP) were assayed by high performance liquid chromatography (HPLC). Daily water consumption, urine weight, urine specific gravity, and urine excretion of sodium and potassium were measured during the SP treatment.

RESULTS:

Two hours after SP administration, SP was metabolized into canrenone. A significant 14 and 22% decrease in urine potassium excretion was observed at 1 and 2mg/kg, respectively, but not at the two other dose levels. Daily water consumption, urine weight, urine specific gravity, and urine excretion of sodium were not significantly altered by the SP treatment regardless of dose.

CONCLUSIONS:

Repeated oral administration of SP at 1, 2, 4 or 8 mg/kg for 8 days had no effect on water and sodium diuresis in healthy dogs.

PMID:
18024236
DOI:
10.1016/j.jvc.2007.10.002
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center