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Diagn Microbiol Infect Dis. 2008 Mar;60(3):329-31. Epub 2007 Nov 19.

Population pharmacokinetics of micafungin in adult patients.

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Ordway Research Institute, Albany, NY 12208, USA.


We performed population pharmacokinetic analysis of micafungin in adult patients treated with doses between 12.5 and 200 mg/day. Our analysis identified a breakpoint patient weight of 66.3 kg above which serum clearance increased by approximately 50%. Patients with weight >66.3 kg may need larger doses to achieve similar exposures to those <66.3 kg. However, the clinical implications are still unknown.

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