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Bioorg Med Chem Lett. 2008 Jan 1;18(1):414-7. Epub 2007 Nov 6.

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.

Author information

1
Department of Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ulrich.iserloh@spcorp.com

Abstract

Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the most potent inhibitors synthesized to date.

PMID:
18023580
DOI:
10.1016/j.bmcl.2007.10.116
[Indexed for MEDLINE]

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