Format

Send to

Choose Destination
FEBS Lett. 2008 Jan 9;582(1):2-9. Epub 2007 Nov 20.

Nuclear receptors: decoding metabolic disease.

Author information

1
Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010N. Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that regulate development, reproduction, and metabolism of lipids, drugs and energy. The importance of this family of proteins in metabolic disease is exemplified by NR ligands used in the clinic or under exploratory development for the treatment of diabetes mellitus, dyslipidemia, hypercholesterolemia, or other metabolic abnormalities. Genetic studies in humans and rodents support the notion that NRs control a wide variety of metabolic processes by regulating the expression of genes encoding key enzymes, transporters and other proteins involved in metabolic homeostasis. Current knowledge of complex NR metabolic networks is summarized here.

PMID:
18023286
PMCID:
PMC2254310
DOI:
10.1016/j.febslet.2007.11.016
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center