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Trends Endocrinol Metab. 2007 Dec;18(10):393-400.

New pancreas from old: microregulators of pancreas regeneration.

Author information

1
Stem Cells and Diabetes Section, Lab 10, National Center for Cell Science, Ganeshkhind Road, Pune 411007, India.

Abstract

MicroRNAs (miRNAs) are 18-22 nucleotide RNA molecules that mediate post-transcriptional gene silencing, primarily by binding to the 3' untranslated region of their target mRNA. Several studies have demonstrated the role of miRNAs in mouse pancreas development (miR-124a, miR-503, miR-541, miR-214) as well as in insulin secretion (miR-375, miR-9). Pancreatic transcription factors that are temporally expressed during early pancreas development are re-expressed during pancreas regeneration following pancreatectomy in mice. The only exception to this is Neurogenin3 (NGN3). Here, we discuss recent evidence for miRNA-mediated silencing of ngn3, which inhibits endocrine cell development via the classical 'stem cell pathway' during mouse pancreatic regeneration, thereby favoring beta-cell regeneration.

PMID:
18023200
DOI:
10.1016/j.tem.2007.10.001
[Indexed for MEDLINE]

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