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WormBook. 2005 Jun 25:1-9.

Karyotype, ploidy, and gene dosage.

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1
Genetics Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. jah@bioch.ox.ac.uk

Abstract

The normal karyotype of Caenorhabditis elegans, with its five pairs of autosomes and single pair of X chromosomes, is described. General features of chromosomes and global differences between different chromosomal regions are discussed. Abnormal karyotypes, including duplications, deficiencies, inversions, translocations and chromosome fusions are reviewed. The effects of varying ploidy and of varying gene dosage are summarized. Dosage-sensitive genes seem to be rare in C. elegans, and the organism is able to tolerate substantial levels of aneuploidy. However, autosomal hemizygosity for more than about 3% of the total genome may be incompatible with viability.

PMID:
18023124
PMCID:
PMC4781021
DOI:
10.1895/wormbook.1.3.1
[Indexed for MEDLINE]
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