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Surg Oncol Clin N Am. 2007 Oct;16(4):755-74, viii.

Tumor microenvironment and immune escape.

Author information

1
Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213-1863, USA. ferrones@upmc.edu

Abstract

This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment. Specifically, we discuss the negative impact of regulatory T cells and T-cell apoptosis on the tumor antigen-specific cytotoxic T lymphocyte response. We also discuss changes in the expression of histocompatibility antigens by tumor cells, which may affect tumor cell-immune cell interactions.

PMID:
18022543
DOI:
10.1016/j.soc.2007.08.004
[Indexed for MEDLINE]
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