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Cell. 2007 Nov 16;131(4):796-808.

CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.

Author information

1
Max Planck Institute of Experimental Medicine, Department of Molecular Neurobiology, Hermann-Rein-Str. 3, D-37075 Göttingen, Germany.

Abstract

Before transmitter-filled synaptic vesicles can fuse with the plasma membrane upon stimulation they have to be primed to fusion competence. The regulation of this priming process controls the strength and plasticity of synaptic transmission between neurons, which in turn determines many complex brain functions. We show that CAPS-1 and CAPS-2 are essential components of the synaptic vesicle priming machinery. CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, which causes a selective impairment of fast phasic transmitter release. Increases in the intracellular Ca(2+) levels can transiently revert this defect. Our findings demonstrate that CAPS proteins generate and maintain a highly fusion competent synaptic vesicle pool that supports phasic Ca(2+) triggered release of transmitters.

PMID:
18022372
DOI:
10.1016/j.cell.2007.11.002
[Indexed for MEDLINE]
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