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J Nat Prod. 2007 Dec;70(12):2010-3. Epub 2007 Nov 20.

Antioxidant phenylpropanoid-substituted epicatechins from Trichilia catigua.

Author information

1
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.

Abstract

Two new phenylpropanoid-substituted epicatechins, namely, catiguanin A ( 1) and catiguanin B ( 2), were isolated from the bark of Trichilia catigua along with four known compounds, cinchonain Ia ( 3), cinchonain Ib ( 4), cinchonain Ic ( 5), and cinchonain Id ( 6). The structures of 1 and 2 were elucidated by analysis of spectroscopic data and by comparison of their NMR data with those of previously reported cinchonains. The isolated compounds exhibited potent antioxidant activity in the alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radical scavenging test, with IC 50 values in the 2.3-9.4 microM range.

PMID:
18020420
DOI:
10.1021/np0703895
[Indexed for MEDLINE]

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