Format

Send to

Choose Destination
See comment in PubMed Commons below
Biomed Biochim Acta. 1991;50(4-6):437-46.

Proteinase-protein inhibitor interaction.

Author information

1
Max-Planck-Institut für Biochemie, Martinsried, Germany.

Abstract

Until recently, the "substrate-like" "canonical" inhibition by the "small" serine proteinase inhibitors, and the product-like inhibition by the carboxypeptidase inhibitor, provided the only models for protein inhibitor-proteinase interactions. The recently published structures of cystatin/stefin-papain complexes and of hirudin-thrombin complexes reveal novel modes of interactions of only partial substrate-like character. Despite considerable progress in understanding the native-cleaved transition of the serpins, the mechanisms of their interaction with their cognate serine proteinases is still a matter of conjecture.

PMID:
1801707
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center