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J Infect Dis. 2007 Nov 15;196(10):1465-73. Epub 2007 Oct 31.

Abrupt emergence of diverse species B adenoviruses at US military recruit training centers.

Author information

  • 1Respiratory Disease Laboratory, Department of Defense Center for Deployment Health Research, Naval Health Research Center, San Diego, CA 92186, USA. david.metzgar@med.navy.mil

Abstract

BACKGROUND:

Adenoviruses (Ads) cause continuous outbreaks of acute respiratory disease (ARD) in US military training facilities. In 1996, the loss of vaccines targeting the dominant recruit-associated serotypes precipitated the reemergence of Ads in these populations. Between 1999 and 2002, serotype 4 accounted for >95% of Ads isolated from recruits and for >50% of ARD cases in training facilities (15,000 cases/year).

METHODS:

Ads (n=1867) collected between 2002 and 2006 from recruits with ARD at 8 military training facilities in the United States were serotyped by serum neutralization and polymerase chain reaction.

RESULTS:

The dominance of Ad4 continued through 2005, followed by a simultaneous emergence of diverse species B serotypes at the majority of sites. This included the subspecies B1 serotypes 3, 7, and 21 and the subspecies B2 serotype 14. Ad14 was the most prevalent species B serotype, appearing in high numbers at 3 sites and becoming dominant at 1.

CONCLUSIONS:

Subspecies B2 Ads have rarely been associated with ARD, and only in Eurasia. This survey represents the first report of AdB2-associated ARD in the Western Hemisphere. The simultaneous emergence of several species B Ads suggests a common external source (the civilian population) and a decrease in preexisting immunity to species B Ads.

PMID:
18008225
DOI:
10.1086/522970
[PubMed - indexed for MEDLINE]
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