Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2007 Dec;7(12):942-53.

Specificity of T-cell alloreactivity.

Author information

1
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Abstract

T-cell alloreactivity is a well-established phenomenon, but its molecular basis has remained enigmatic. Although there are differences between T-cell recognition of conventional and allogeneic antigens, it has become increasingly clear that they share many similarities. Recent insights into the specificity of the T-cell receptor (TCR) for peptide and the seeming intrinsic affinity of the TCR for the surface of the MHC molecule have provided a better understanding of how the TCR and peptide-MHC complexes interact. Here, we highlight the similarities and differences between conventional and allogeneic recognition of TCR-peptide-MHC complexes, and discuss how our view of allorecognitionhas changed, as well as the implications for TCR specificity and T-cell development.

PMID:
18007679
DOI:
10.1038/nri2200
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center