Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Genet. 2007 Dec;8(12):932-42.

Evolutionary developmental biology and genomics.

Author information

1
Institute of Neuroscience, 1425 East 13th Avenue, University of Oregon, Eugene, Oregon 97403, USA.

Abstract

Reciprocal questions often frame studies of the evolution of developmental mechanisms. How can species share similar developmental genetic toolkits but still generate diverse life forms? Conversely, how can similar forms develop from different toolkits? Genomics bridges the gap between evolutionary and developmental biology, and can help answer these evo-devo questions in several ways. First, it informs us about historical relationships, thus orienting the direction of evolutionary diversification. Second, genomics lists all toolkit components, thereby revealing contraction and expansion of the genome and suggesting mechanisms for evolution of both developmental functions and genome architecture. Finally, comparative genomics helps us to identify conserved non-coding elements and their relationship to genome architecture and development.

PMID:
18007650
DOI:
10.1038/nrg2226
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center