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Curr Opin Cell Biol. 2007 Dec;19(6):685-90. Epub 2007 Nov 19.

Multitasking by pVHL in tumour suppression.

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  • 1Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland.

Abstract

Functional inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene product, pVHL, leads to cancer in humans. It is widely accepted that pVHL functions to destabilise hypoxia inducible factor alpha (HIFalpha) subunits, key effectors of the hypoxia signalling pathway. However, growing evidence indicates that tumour suppression by pVHL also involves the control of a wide variety of HIFalpha-independent processes including microtubule dynamics, primary cilium maintenance, cell proliferation, neuronal apoptosis, extracellular matrix deposition and responses to DNA damage. Moreover, it is becoming apparent that tumour initiation requires not only VHL mutation but also the alteration of additional cooperating cancer pathways. These studies are beginning to provide insights into the signalling networks involving pVHL that normally control diverse cellular processes and how disruption of these networks leads to tumour formation.

PMID:
18006292
DOI:
10.1016/j.ceb.2007.10.001
[PubMed - indexed for MEDLINE]
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