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Adv Drug Deliv Rev. 2008 Jan 14;60(2):199-214. Epub 2007 Oct 11.

Controlled differentiation of stem cells.

Author information

1
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Abstract

The extracellular microenvironment plays a significant role in controlling cellular behavior. Identification of appropriate biomaterials that support cellular attachment, proliferation and, most importantly in the case of human embryonic stem cells, lineage-specific differentiation is critical for tissue engineering and cellular therapy. In addition to growth factors and morphogenetic factors known to induce lineage commitment of stem cells, a number of scaffolding materials, including synthetic and naturally-derived biomaterials, have been utilized in tissue engineering approaches to direct differentiation. This review focuses on recent emerging findings and well-characterized differentiation models of human embryonic stem cells. Additionally, we also discuss about various strategies that have been used in stem cell expansion.

PMID:
18006108
PMCID:
PMC2712932
DOI:
10.1016/j.addr.2007.08.036
[Indexed for MEDLINE]
Free PMC Article

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