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Cell Host Microbe. 2007 Oct 11;2(4):207-9.

Influenza A virus PB1-F2: a small protein with a big punch.

Author information

1
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

Virulence factors, such as the recently discovered PB1-F2, contribute to the pathogenesis and comorbidity of influenza A virus. In this issue of Cell Host & Microbe, McAuley et al. characterize the role of PB1-F2, including in the pandemic 1918 virus, in causing increased lung pathology and fatal pneumococcus infection in mice. This work sheds light on the mechanisms of pathogenicity during influenza A virus infections.

PMID:
18005736
DOI:
10.1016/j.chom.2007.09.010
[Indexed for MEDLINE]
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