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Cell Host Microbe. 2007 Sep 13;2(3):143-6.

Junctional gating: the achilles' heel of epithelial cells in pathogen infection.

Author information

1
Institute of Zoology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. ufgreber@zool.uzh.ch

Abstract

Mucosal epithelial cells are a major barrier restricting pathogen entry and, paradoxically, an important entry port for respiratory and enteric viruses. Elegant studies in this issue of Cell Host & Microbe describe how coxsackievirus B3 (related to human poliovirus) infects polarized epithelial cells by engaging two transmembrane proteins of the tight junctions, occludin and CAR. A distinctive endocytic mechanism opens the junctions and gates infectious virus entry.

PMID:
18005729
DOI:
10.1016/j.chom.2007.08.004
[Indexed for MEDLINE]
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