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Cell Host Microbe. 2007 Jun 14;1(4):244-6.

Epigenetic regulation of host response to LPS: causing tolerance while avoiding Toll errancy.

Author information

1
Unité de Pathogénie Microbienne Moléculaire and Unité INSERM 786, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France. arbibe@pasteur.fr

Abstract

Tolerance to lipopolysaccharide (LPS) is part of the host's strategy to avoid harmful excessive inflammation in the presence of Gram-negative commensals and pathogens. Macrophages are the major cells endowed with this property, allowing them to limit expression of proinflammatory genes while maintaining efficient antimicrobial functions. In a recent paper, Foster et al. (2007) demonstrate that this subtle balance is established and imprinted via epigenetic regulation.

PMID:
18005703
DOI:
10.1016/j.chom.2007.05.011
[Indexed for MEDLINE]
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