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Cell Host Microbe. 2007 May 17;1(3):167-74.

Intercepting host MAPK signaling cascades by bacterial type III effectors.

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1
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

The evolutionarily conserved MAP kinase (MAPK) cascades play essential roles in plant and animal innate immunity. A recent explosion of research has uncovered a myriad of virulence strategies used by pathogenic bacteria to intercept MAPK signaling through diverse type III effectors injected into host cells. Here, we review the latest literature and discuss the various mechanisms that pathogenic bacteria use to manipulate host MAPK signaling cascades.

PMID:
18005696
DOI:
10.1016/j.chom.2007.04.008
[Indexed for MEDLINE]
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