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Cell Host Microbe. 2007 Mar 15;1(1):13-22.

Bacterial interference of ubiquitination and deubiquitination.

Author information

1
Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom.

Abstract

Ubiquitination and deubiquitination regulate several essential cellular processes such as protein degradation, cell-cycle progression, signaling, and DNA repair. Given the importance of these processes, it is not surprising that many microbes have developed the means to interfere with different stages of ubiquitin pathways to promote their survival and replication. This review focuses on virulence proteins of bacterial pathogens that mediate these effects and summarizes our current understanding of their actions.

PMID:
18005678
DOI:
10.1016/j.chom.2007.02.003
[Indexed for MEDLINE]
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