Send to

Choose Destination
See comment in PubMed Commons below
Eur J Anaesthesiol. 2008 Feb;25(2):89-96. Epub 2007 Nov 16.

Optimal ventilator settings in acute lung injury and acute respiratory distress syndrome.

Author information

Mayo Clinic College of Medicine, Division of Pulmonary and Critical Care Medicine, Rochester, MN 55905, USA.


Despite recent advances in intensive care medicine, acute lung injury and its more severe form, acute respiratory distress syndrome pose major therapeutic problems. While mechanical ventilation is integral to the care of these patients, its adverse consequences including ventilator-induced lung injury are determinants of disease progression and prognosis. Among several important ventilator parameters, the use of low tidal volumes is probably the most important feature of lung-protective mechanical ventilation. Intensivists should be trained to recognize acute lung injury and acute respiratory distress syndrome and encouraged to use low-tidal-volume ventilation in clinical practice. Alternative modes of ventilation such as high-frequency ventilation and prone position should be reserved for selected patients in whom conventional lung-protective ventilation strategies have failed.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center