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Org Biomol Chem. 2007 Dec 7;5(23):3745-57. Epub 2007 Oct 1.

Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments.

Author information

1
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan.

Abstract

To address the specific challenges of cancer therapy and diagnosis, a number of approaches have been advocated for the development of tumor-targeting antitumor drugs/prodrugs and non-invasive tumor molecular imaging probes. These intelligent drugs and probes are constructed from multi-functional molecular systems. This review focuses on the molecular design of drugs and imaging probes that target tumor-specific microenvironments such as angiogenesis and hypoxia.

PMID:
18004453
DOI:
10.1039/b711244k
[Indexed for MEDLINE]

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