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Nat Rev Cancer. 2007 Dec;7(12):911-24.

Oncogenes and tumour suppressors take on centrosomes.

Author information

1
Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA. Kenji.Fukasawa@Moffitt.org

Abstract

Chromosome instability, which is equated to mitotic defects and consequential chromosome segregation errors, provides a formidable basis for the acquisition of further malignant phenotypes during tumour progression. Centrosomes have a crucial role in the formation of bipolar mitotic spindles, which are essential for accurate chromosome segregation. Mutations of certain oncogenic and tumour-suppressor proteins directly induce chromosome instability by disrupting the normal function and numeral integrity of centrosomes. How these proteins control centrosome duplication and function, and how their mutational activation and/or inactivation results in numeral and functional centrosome abnormalities, is discussed in this Review.

PMID:
18004399
DOI:
10.1038/nrc2249
[Indexed for MEDLINE]
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