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J Occup Environ Med. 2007 Oct;49(10):1097-104.

Maternal arsenic exposure associated with low birth weight in Bangladesh.

Author information

1
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

Abstract

OBJECTIVE:

To characterize the effects of maternal arsenic exposure on birth weight.

METHODS:

Hair, toenail, and drinking water samples were collected from pregnant women (n = 52) at multiple time points during pregnancy and from their newborns after birth. Total arsenic was measured using inductively coupled plasma-mass spectrometry. The association between arsenic and birth weight was investigated using linear and logistic regression models.

RESULTS:

Maternal hair arsenic measured early in pregnancy was associated with decreased birth weight (beta = -193.5 +/- 90.0 g, P = 0.04). Maternal hair and drinking water arsenic levels measured at first prenatal visit were significantly correlated with newborn hair arsenic level (rho = 0.32, P = 0.04 and rho = 0.31, P = 0.04).

CONCLUSIONS:

Results suggest that maternal arsenic exposure early in pregnancy negatively affects newborn birth weight and that maternal hair provides the best integrated measure of arsenic exposure.

PMID:
18000415
DOI:
10.1097/JOM.0b013e3181566ba0
[Indexed for MEDLINE]

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