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FEBS Lett. 2007 Dec 11;581(29):5591-6. Epub 2007 Nov 13.

p38MAP Kinase activity is required for human primary adipocyte differentiation.

Author information

1
INSERM, U 568, IFR50, F-06107, Nice, France. myriam.aouadi@umassmed.edu

Abstract

Little is known about the role of p38MAPK in human adipocyte differentiation. Here we showed that p38MAPK activity increases during human preadipocytes differentiation. Pharmacological inhibition of p38MAPK during adipocyte differentiation of primary human preadipocytes markedly reduced triglycerides accumulation and adipocyte markers expression. Cell cycle arrest or proliferation was not affected by p38MAPK inhibition. Although induction of C/EBPbeta was not altered by the p38MAPK inhibitor, its phosphorylation on Threonine(188) was decreased as well as PPARgamma expression. These results indicate that p38MAPK plays a positive role in human adipogenesis through regulation of C/EBPbeta and PPARgamma factors.

PMID:
17997987
DOI:
10.1016/j.febslet.2007.10.064
[Indexed for MEDLINE]
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