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Curr Opin Cell Biol. 2007 Dec;19(6):612-7. Epub 2007 Nov 9.

Wnt/beta-catenin signaling in adipogenesis and metabolism.

Author information

1
Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA. tcp@unmich.edu

Abstract

Adipocyte differentiation consists of a complex series of events in which scores of cellular and extracellular factors interact to transform a fibroblast-like preadipocyte into a mature, lipid-filled adipocyte. Many of the pathways influencing this process have been identified using well-characterized preadipocyte culture systems and have subsequently been confirmed in animal models. Research conducted over the past decade has established the Wnt/beta-catenin signaling pathway as an important regulator of adipocyte differentiation. While initial reports implicated activators of Wnt/beta-catenin signaling as potent inhibitors of adipogenesis, recent investigations of mesenchymal cell fate, obesity, and type 2 diabetes highlight significant additional roles for Wnt signaling in metabolism and adipocyte biology.

PMID:
17997088
PMCID:
PMC2709272
DOI:
10.1016/j.ceb.2007.09.014
[Indexed for MEDLINE]
Free PMC Article

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