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Rev Bras Cir Cardiovasc. 2007 Jan-Mar;22(1):87-95.

Mechanical forces and human saphenous veins: coronary artery bypass graft implications.

[Article in English, Portuguese]

Author information

1
Surgery and Anatomy Department of the Medical School in Ribeirão Preto of the University of São Paulo.

Abstract

Vascular endothelial cells are exposed to a variety of in vivo mechanical forces, specifically, shear stress for the blood flow, tensile stress from the compliance of the vessel wall and the hydrostatic pressure from containment of blood within inside the vasculature. Many authors studied hemodynamic, functional and morphological human saphenous veins alterations caused by these different forces with conflictant results. This review text was motivated with the specific aim of analyze literature data and some experimental data carried out in our laboratory. The adopted review subjects were: 1) Endothelial responses and gene regulation to shear stress; 2) Effects of the hydrostatic pressure in the endothelial cell morphology, gene expression of the endothelial cellular surface and proliferation of endothelial cells; 3) Effects of the traction on the human saphenous vein endothelium.

PMID:
17992309
DOI:
10.1590/s0102-76382007000100016
[Indexed for MEDLINE]

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