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J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8.

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).

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1
Pfizer Global Research and Development, 700 Chesterfield Parkway, Chesterfield, MO 63017, USA.

Abstract

Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.

PMID:
17991750
DOI:
10.1074/jbc.M705879200
[Indexed for MEDLINE]
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