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J Biol Chem. 2008 Jan 11;283(2):1026-33. Epub 2007 Nov 8.

Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

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Biotech Research and Innovation Centre, Bioinformatics Centre, University of Copenhagen, DK-2200 N Copenhagen, Denmark.


MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.

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